Transfusion as an Inflammation Hit: Knowns and Unknowns
نویسندگان
چکیده
Transfusion of blood cell components is frequent in the therapeutic arsenal; it is globally safe or even very safe. At present, residual clinical manifestations are principally inflammatory in nature. If some rare clinical hazards manifest as acute inflammation symptoms of various origin, most of them linked with conflicting and undesirable biological material accompanying the therapeutic component (infectious pathogen, pathogenic antibody, unwanted antigen, or allergen), the general feature is subtler and less visible, and essentially consists of alloimmunization or febrile non-hemolytic transfusion reaction. The present essay aims to present updates in hematology and immunology that help understand how, when, and why subclinical inflammation underlies alloimmunization and circumstances characteristic of red blood cells and - even more frequently - platelets that contribute inflammatory mediators. Modern transfusion medicine makes sustained efforts to limit such inflammatory hazards; efforts can be successful only if one has a clear view of each element's role.
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RUPERT A. COLLINS1∗ AND ROBERT H. CRUICKSHANK2 1Laboratório de Evolução e Genética Animal, Departamento de Biologia, Universidade Federal do Amazonas, Av. Rodrigo Otávio, Manaus, Amazonas, Brazil and 2Department of Ecology, Faculty of Agriculture and Life Sciences, Lincoln University, Lincoln 7647, Canterbury, New Zealand ∗Correspondence to be sent to: Departamento de Biologia, Universidade Fed...
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